Thrombin inhibitors identified by computer-assisted multiparameter design

Here, we present a series of thrombin inhibitors that were generated by using powerful computer-assisted multiparameter optimization process. The process was organized in design cycles, starting with a set of randomly chosen molecules. Each cycle combined combinatorial synthesis, multiparameter char...

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Autori principali: Riester, Daniel, Wirsching, Frank, Salinas, Gabriela, Keller, Martina, Gebinoga, Michael, Kamphausen, Stefan, Merkwirth, Christian, Goetz, Ruediger, Wiesenfeldt, Martin, Stürzebecher, Jörg, Bode, Wolfram, Friedrich, Rainer, Thürk, Marcel, Schwienhorst, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150832/
https://ncbi.nlm.nih.gov/pubmed/15937115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501983102
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