The ornithodorin-thrombin crystal structure, a key to the TAP enigma?

Ornithodorin, isolated from the blood sucking soft tick Ornithodoros moubata, is a potent (Ki = 10(-12) M) and highly selective thrombin inhibitor. Internal sequence homology indicates a two domain protein. Each domain resembles the Kunitz inhibitor basic pancreatic trypsin inhibitor (BPTI) and also...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	van de Locht, A, Stubbs, M T, Bode, W, Friedrich, T, Bollschweiler, C, Höffken, W, Huber, R
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452422/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8947023/
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