Stability of the Human Papillomavirus Type 18 E2 Protein Is Regulated by a Proteasome Degradation Pathway through Its Amino-Terminal Transactivation Domain

Eitemau Tebyg

• The Human Papillomavirus Type 18 E2 Protein Is a Cell Cycle-Dependent Target of the SCF(Skp2) Ubiquitin Ligase
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• Proteasomal Degradation of the Papillomavirus E2 Protein Is Inhibited by Overexpression of Bromodomain-Containing Protein 4
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• Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis.
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• Human Papillomavirus Type 18 E6 Protein Binds the Cellular PDZ Protein TIP-2/GIPC, Which Is Involved in Transforming Growth Factor β Signaling and Triggers Its Degradation by the Proteasome
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• Functional Interaction of the Bovine Papillomavirus E2 Transactivation Domain with TFIIB
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