Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic Domain

The Nef protein of the simian and human immunodeficiency viruses is known to directly bind and downregulate the CD4 receptor. Although the molecular mechanism is well understood, direct binding of Nef and CD4 is difficult to demonstrate and is believed to be of low affinity. Applying nuclear magneti...

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Bibliographic Details
Main Authors: Preusser, Andrea, Briese, Lars, Baur, Andreas S., Willbold, Dieter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114886/
https://ncbi.nlm.nih.gov/pubmed/11264384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3960-3964.2001
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