Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.

Ítems similars

• Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase.
  per: Heyworth, C M, et al.
  Publicat: (1983)
• Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity.
  per: Strassheim, D, et al.
  Publicat: (1990)
• Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon.
  per: Murphy, G J, et al.
  Publicat: (1989)
• Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes.
  per: Irvine, F J, et al.
  Publicat: (1988)
• Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
  per: McKenzie, F R, et al.
  Publicat: (1990)