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Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase.

Insulin failed to exert an effect on the basal and glucagon- and guanosine 5'-[beta, gamma-imido]-triphosphate-stimulated adenylate cyclase activities of hepatocyte membranes. In the presence of high GTP (0.1 mM) concentrations, however, insulin was shown to inhibit adenylate cyclase activity....

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Библиографические подробности
Главные авторы: Heyworth, C M, Houslay, M D
Формат: Artigo
Язык:Inglês
Опубликовано: 1983
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1152279/
https://ncbi.nlm.nih.gov/pubmed/6311187
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