Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity.

Lignende værker

• Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.
  af: Gawler, D, et al.
  Udgivet: (1988)
• Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon.
  af: Murphy, G J, et al.
  Udgivet: (1989)
• Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats.
  af: Strassheim, D, et al.
  Udgivet: (1991)
• Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
  af: McKenzie, F R, et al.
  Udgivet: (1990)
• Exchange of guanine nucleotide between GTP-binding proteins that regulate neuronal adenylate cyclase.
  af: Hatta, S, et al.
  Udgivet: (1986)