Epidermal Powder Immunization Induces both Cytotoxic T-Lymphocyte and Antibody Responses to Protein Antigens of Influenza and Hepatitis B Viruses

Cytotoxic T lymphocytes (CTL) play a vital role in host defense against viral and intracellular bacterial infections. However, nonreplicating vaccines administered by intramuscular injection using a syringe and needle elicit predominantly humoral responses and not CTL responses. Here we report that...

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Bibliografiske detaljer
Main Authors: Chen, Dexiang, Weis, Kathleen F., Chu, Qili, Erickson, Cherie, Endres, Ryan, Lively, Chris R., Osorio, Jorge, Payne, Lendon G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114750/
https://ncbi.nlm.nih.gov/pubmed/11689645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.23.11630-11640.2001
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