Unique Monoclonal Antibody Recognizing the Third Extracellular Loop of CXCR4 Induces Lymphocyte Agglutination and Enhances Human Immunodeficiency Virus Type 1-Mediated Syncytium Formation and Productive Infection

To increase insight into the structural basis of CXCR4 utilization in human immunodeficiency virus type 1 (HIV-1) infection, a new generation of three monoclonal antibodies (MAbs) was developed in WKA rats. The A80 MAb, which binds an epitope in the third extracellular loop (ECL3) of CXCR4, has uniq...

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Bibliografiska uppgifter
Huvudupphovsmän: Tanaka, Reiko, Yoshida, Atsushi, Murakami, Tsutomu, Baba, Eishi, Lichtenfeld, Julliane, Omori, Takeru, Kimura, Tohru, Tsurutani, Naomi, Fujii, Nobutaka, Wang, Zi-Xuan, Peiper, Stephen C., Yamamoto, Naoki, Tanaka, Yuetsu
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2001
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC114740/
https://ncbi.nlm.nih.gov/pubmed/11689635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.23.11534-11543.2001
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