Multiple Effects of Codon Usage Optimization on Expression and Immunogenicity of DNA Candidate Vaccines Encoding the Human Immunodeficiency Virus Type 1 Gag Protein

We have analyzed the influence of codon usage modifications on the expression levels and immunogenicity of DNA vaccines, encoding the human immunodeficiency virus type 1 (HIV-1) group-specific antigen (Gag). In the presence of Rev, an expression vector containing the wild-type (wt) gag gene flanked...

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Detalhes bibliográficos
Main Authors: Deml, Ludwig, Bojak, Alexandra, Steck, Stephanie, Graf, Marcus, Wild, Jens, Schirmbeck, Reinhold, Wolf, Hans, Wagner, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114679/
https://ncbi.nlm.nih.gov/pubmed/11602739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.22.10991-11001.2001
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