CD8(+) T Lymphocytes Mediate Borna Disease Virus-Induced Immunopathology Independently of Perforin

Perforin-mediated lysis of target cells is the major antiviral effector mechanism of CD8(+) T lymphocytes. We have analyzed the role of perforin in a mouse model for CD8(+) T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus. When a defective perforin gene was...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Hausmann, Jürgen, Schamel, Karin, Staeheli, Peter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114620/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.21.10460-10466.2001
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