CD8(+) T Lymphocytes Mediate Borna Disease Virus-Induced Immunopathology Independently of Perforin

Perforin-mediated lysis of target cells is the major antiviral effector mechanism of CD8(+) T lymphocytes. We have analyzed the role of perforin in a mouse model for CD8(+) T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus. When a defective perforin gene was...

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Hlavní autoři: Hausmann, Jürgen, Schamel, Karin, Staeheli, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC114620/
https://ncbi.nlm.nih.gov/pubmed/11581414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10460-10466.2001
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