CD8(+) T Lymphocytes Mediate Borna Disease Virus-Induced Immunopathology Independently of Perforin
Perforin-mediated lysis of target cells is the major antiviral effector mechanism of CD8(+) T lymphocytes. We have analyzed the role of perforin in a mouse model for CD8(+) T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus. When a defective perforin gene was...
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| Publicado en: | J Virol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114620/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.21.10460-10466.2001 |
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