Mutation of the Methylated tRNA [Formula: see text] Residue A58 Disrupts Reverse Transcription and Inhibits Replication of Human Immunodeficiency Virus Type 1

Cellular tRNA [Formula: see text] serves as the primer for reverse transcription of human immunodeficiency virus type 1 (HIV-1). tRNA [Formula: see text] interacts directly with HIV-1 reverse transcriptase (RT), is packaged into viral particles, and anneals to the primer-binding site (PBS) of the HI...

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Detalhes bibliográficos
Main Authors: Renda, Matthew J., Rosenblatt, Joseph D., Klimatcheva, Ekaterina, Demeter, Lisa M., Bambara, Robert A., Planelles, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114538/
https://ncbi.nlm.nih.gov/pubmed/11559799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.20.9671-9678.2001
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