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Frameshift Signal Transplantation and the Unambiguous Analysis of Mutations in the Yeast Retrotransposon Ty1 Gag-Pol Overlap Region

The yeast retrotransposon Ty1 encodes a 7-nucleotide RNA sequence that directs a programmed, +1 ribosomal frameshifting event required for Gag-Pol translation and retrotransposition. We report mutations that block frameshifting, which can be suppressed in cis by “transplanting” the frameshift signal...

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Autori principali: Lawler, Joseph F., Merkulov, Gennady V., Boeke, Jef D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC114403/
https://ncbi.nlm.nih.gov/pubmed/11435555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.15.6769-6775.2001
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