Poliovirus/Hepatitis C Virus (Internal Ribosomal Entry Site-Core) Chimeric Viruses: Improved Growth Properties through Modification of a Proteolytic Cleavage Site and Requirement for Core RNA Sequences but Not for Core-Related Polypeptides

H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412–1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open readin...

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Main Authors: Zhao, Wei Dong, Wimmer, Eckard, Lahser, Frederick C.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 1999
主題:
Replication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC103979/
https://ncbi.nlm.nih.gov/pubmed/9882360
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