Attenuation of Equine Influenza Viruses through Truncations of the NS1 Protein

Equine influenza is a common disease of the horse, causing significant morbidity worldwide. Here we describe the establishment of a plasmid-based reverse genetics system for equine influenza virus. Utilizing this system, we generated three mutant viruses encoding carboxy-terminally truncated NS1 pro...

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Hlavní autoři: Quinlivan, Michelle, Zamarin, Dmitriy, García-Sastre, Adolfo, Cullinane, Ann, Chambers, Thomas, Palese, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143746/
https://ncbi.nlm.nih.gov/pubmed/15956587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.13.8431-8439.2005
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