Mutations in the NS1 Protein of Swine Influenza Virus Impair Anti-Interferon Activity and Confer Attenuation in Pigs

It has been shown previously that the nonstructural protein NS1 of influenza virus is an alpha/beta interferon (IFN-α/β) antagonist, both in vitro and in experimental animal model systems. However, evidence of this function in a natural host has not yet been obtained. Here we investigated the role o...

Full description

Saved in:
Bibliographic Details
Main Authors: Solórzano, Alicia, Webby, Richard J., Lager, Kelly M., Janke, Bruce H., García-Sastre, Adolfo, Richt, Jürgen A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143661/
https://ncbi.nlm.nih.gov/pubmed/15919908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7535-7543.2005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items