Human Cytomegalovirus Up-Regulates the Phosphatidylinositol 3-Kinase (PI3-K) Pathway: Inhibition of PI3-K Activity Inhibits Viral Replication and Virus-Induced Signaling

Infection of quiescent fibroblasts with human cytomegalovirus (HCMV) was found to cause a rapid activation of cellular phosphatidylinositol 3-kinase (PI3-K). Maximum PI3-K activation occurred from 15 to 30 min postinfection. This activation was transient, and by 2 h postinfection (hpi), PI3-K activi...

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Main Authors: Johnson, Robert A., Wang, Xin, Ma, Xiu-Li, Huong, Shu-Mei, Huang, Eng-Shang
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114318/
https://ncbi.nlm.nih.gov/pubmed/11390604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.6022-6032.2001
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