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Mapping the Determinants of the CCR5 Amino-Terminal Sulfopeptide Interaction with Soluble Human Immunodeficiency Virus Type 1 gp120-CD4 Complexes

CD4 and CCR5 mediate fusion and entry of R5 human immunodeficiency virus type 1 (HIV-1) strains. Sulfotyrosine and other negatively charged residues in the CCR5 amino-terminal domain (Nt) are crucial for gp120 binding and viral entry. We previously showed that a soluble gp120-CD4 complex specificall...

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Udgivet i:J Virol
Principais autores: Cormier, Emmanuel G., Tran, Diep N. H., Yukhayeva, Liyana, Olson, William C., Dragic, Tatjana
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114266/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11356961/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.12.5541-5549.2001
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