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Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

The inactivation of glycogen synthase kinase (GSK)3 has been proposed to play important roles in insulin and Wnt signalling. To define the role that inactivation of GSK3 plays, we generated homozygous knockin mice in which the protein kinase B phosphorylation sites on GSK3α (Ser21) and GSK3β (Ser9)...

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Detalhes bibliográficos
Main Authors: McManus, Edward J, Sakamoto, Kei, Armit, Laura J, Ronaldson, Leah, Shpiro, Natalia, Marquez, Rodolfo, Alessi, Dario R
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142569/
https://ncbi.nlm.nih.gov/pubmed/15791206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600633
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