“Stealth” Adenoviruses Blunt Cell-Mediated and Humoral Immune Responses against the Virus and Allow for Significant Gene Expression upon Readministration in the Lung

Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors. First-generation viruses with E1a and E1b deleted are limited by transient expression of the transgene and substantial inflammatory responses. Gene transfer is also significantly curtailed following a second...

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Pubblicato in:	J Virol
Autori principali:	Croyle, Maria A., Chirmule, Narendra, Zhang, Yi, Wilson, James M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Gene Therapy
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11312351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.10.4792-4801.2001
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