“Stealth” Adenoviruses Blunt Cell-Mediated and Humoral Immune Responses against the Virus and Allow for Significant Gene Expression upon Readministration in the Lung

Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors. First-generation viruses with E1a and E1b deleted are limited by transient expression of the transgene and substantial inflammatory responses. Gene transfer is also significantly curtailed following a second...

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Detaylı Bibliyografya

Yayımlandı:	J Virol
Asıl Yazarlar:	Croyle, Maria A., Chirmule, Narendra, Zhang, Yi, Wilson, James M.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 2001
Konular:	Gene Therapy
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11312351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.10.4792-4801.2001
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