Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

Success in treating hepatitis B virus (HBV) infection with nucleoside analog drugs like lamivudine is limited by the emergence of drug-resistant viral strains upon prolonged therapy. The predominant lamivudine resistance mutations in HBV-infected patients are Met552IIe and Met552Val (Met552Ile/Val),...

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Detalhes bibliográficos
Main Authors: Das, Kalyan, Xiong, Xiaofeng, Yang, Huiling, Westland, Christopher E., Gibbs, Craig S., Sarafianos, Stefan G., Arnold, Edward
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114232/
https://ncbi.nlm.nih.gov/pubmed/11312349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.10.4771-4779.2001
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