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Coupling between Replication and Packaging of Flavivirus RNA: Evidence Derived from the Use of DNA-Based Full-Length cDNA Clones of Kunjin Virus

In order to study whether flavivirus RNA packaging is dependent on RNA replication, we generated two DNA-based Kunjin virus constructs, pKUN1 and pKUN1dGDD, allowing continuous production of replicating (wild-type) and nonreplicating (with a deletion of the NS5 gene RNA-polymerase motif GDD) full-le...

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Publicado no:J Virol
Principais autores: Khromykh, Alexander A., Varnavski, Andrei N., Sedlak, Petra L., Westaway, Edwin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114216/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11312333/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.10.4633-4640.2001
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