Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma

Immunotherapy for the treatment of metastatic melanoma remains a major clinical challenge. The melanoma microenvironment may lead to local T cell tolerance in part through downregulation of costimulatory molecules, such as B7.1 (CD80). We report the results from the first clinical trial, to our know...

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Autors principals: Kaufman, Howard L., DeRaffele, Gail, Mitcham, Josephine, Moroziewicz, Dorota, Cohen, Seth M., Hurst-Wicker, Karl S., Cheung, Ken, Lee, David S., Divito, Joseph, Voulo, Magalese, Donovan, Julie, Dolan, Kate, Manson, Kelledy, Panicali, Dennis, Wang, Ena, Hörig, Heidi, Marincola, Francesco M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142116/
https://ncbi.nlm.nih.gov/pubmed/15937544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24624
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