Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival

Herpes simplex virus (HSV) ICP0 can effectively activate gene expression from otherwise silent promoters contained on persisting viral genomes. However, the expression of high levels of ICP0, as from ICP4(−) HSV type 1 (HSV-1) vectors, results in marked toxicity. We have analyzed the results of ICP0...

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Podrobná bibliografie

Vydáno v:	J Virol
Hlavní autoři:	Hobbs, William E., Brough, Douglas E., Kovesdi, Imre, DeLuca, Neal A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Virus-Cell Interactions
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.7.3391-3403.2001
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