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Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
Herpes simplex virus (HSV) ICP0 can effectively activate gene expression from otherwise silent promoters contained on persisting viral genomes. However, the expression of high levels of ICP0, as from ICP4(−) HSV type 1 (HSV-1) vectors, results in marked toxicity. We have analyzed the results of ICP0...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC114132/ https://ncbi.nlm.nih.gov/pubmed/11238865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3391-3403.2001 |
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