Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival

Herpes simplex virus (HSV) ICP0 can effectively activate gene expression from otherwise silent promoters contained on persisting viral genomes. However, the expression of high levels of ICP0, as from ICP4(−) HSV type 1 (HSV-1) vectors, results in marked toxicity. We have analyzed the results of ICP0...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Hobbs, William E., Brough, Douglas E., Kovesdi, Imre, DeLuca, Neal A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.7.3391-3403.2001
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