Human Immunodeficiency Virus Type 1 Central DNA Flap: Dynamic Terminal Product of Plus-Strand Displacement DNA Synthesis Catalyzed by Reverse Transcriptase Assisted by Nucleocapsid Protein

To terminate the reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome, a final step occurs within the center of the proviral DNA generating a 99-nucleotide DNA flap (6). This step, catalyzed by reverse transcriptase (RT), is defined as a discrete strand displacement (SD) s...

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Main Authors: Hameau, Laurence, Jeusset, Josette, Lafosse, Sophie, Coulaud, Dominique, Delain, Etienne, Unge, Torsten, Restle, Tobias, Le Cam, Eric, Mirambeau, Gilles
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2001
Ábhair:
Replication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC114123/
https://ncbi.nlm.nih.gov/pubmed/11238856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3301-3313.2001
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