Highly Reliable Heterologous System for Evaluating Resistance of Clinical Herpes Simplex Virus Isolates to Nucleoside Analogues

Clinical resistance of herpes simplex virus (HSV) types 1 and 2 to acyclovir (ACV) is usually caused by the presence of point mutations within the coding region of the viral thymidine kinase (TK) gene. The distinction between viral TK mutations involved in ACV resistance or part of viral polymorphis...

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Bibliografiske detaljer
Main Authors: Bestman-Smith, Julie, Schmit, Isabelle, Papadopoulou, Barbara, Boivin, Guy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114104/
https://ncbi.nlm.nih.gov/pubmed/11238837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3105-3110.2001
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