Mutation of SENP1/SuPr-2 Reveals an Essential Role for Desumoylation in Mouse Development

The covalent modification of proteins by the small ubiquitin-like protein SUMO has been implicated in the regulation of numerous biological processes, including nucleocytoplasmic transport, genomic stability, and gene transcription. Sumoylation occurs by a multienzyme process similar to ubiquitinati...

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Main Authors: Yamaguchi, Taihei, Sharma, Prashant, Athanasiou, Meropi, Kumar, Amit, Yamada, Satoru, Kuehn, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140580/
https://ncbi.nlm.nih.gov/pubmed/15923632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.5171-5182.2005
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