Oxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces cerevisiae

Mitochondria contain their own genome, the integrity of which is required for normal cellular energy metabolism. Reactive oxygen species (ROS) produced by normal mitochondrial respiration can damage cellular macromolecules, including mitochondrial DNA (mtDNA), and have been implicated in degenerativ...

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Detalhes bibliográficos
Main Authors: Doudican, Nicole A., Song, Binwei, Shadel, Gerald S., Doetsch, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140570/
https://ncbi.nlm.nih.gov/pubmed/15923634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.5196-5204.2005
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