Oxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces cerevisiae

Mitochondria contain their own genome, the integrity of which is required for normal cellular energy metabolism. Reactive oxygen species (ROS) produced by normal mitochondrial respiration can damage cellular macromolecules, including mitochondrial DNA (mtDNA), and have been implicated in degenerativ...

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Hlavní autoři: Doudican, Nicole A., Song, Binwei, Shadel, Gerald S., Doetsch, Paul W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140570/
https://ncbi.nlm.nih.gov/pubmed/15923634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.5196-5204.2005
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