Mitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins

The mitochondrial genome is a significant target of exogenous and endogenous genotoxic agents; however, the determinants that govern this susceptibility and the pathways available to resist mitochondrial DNA (mtDNA) damage are not well characterized. Here we report that oxidative mtDNA damage is ele...

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Detalhes bibliográficos
Main Authors: O'Rourke, Thomas W., Doudican, Nicole A., Mackereth, Melinda D., Doetsch, Paul W., Shadel, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133882/
https://ncbi.nlm.nih.gov/pubmed/12024022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.12.4086-4093.2002
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