Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models

This study extends earlier reports regarding the in vitro and in vivo efficacies of the nitroimidazopyran PA-824 against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC &...

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Detalhes bibliográficos
Main Authors: Lenaerts, Anne J., Gruppo, Veronica, Marietta, Karen S., Johnson, Christine M., Driscoll, Diane K., Tompkins, Nicholas M., Rose, Jerry D., Reynolds, Robert C., Orme, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140539/
https://ncbi.nlm.nih.gov/pubmed/15917524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2294-2301.2005
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