Population Pharmacokinetics of Abacavir in Plasma and Cerebrospinal Fluid

The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetra...

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Main Authors: Capparelli, Edmund V., Letendre, Scott L., Ellis, Ronald J., Patel, Parul, Holland, Diane, McCutchan, J. Allen
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140502/
https://ncbi.nlm.nih.gov/pubmed/15917556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2504-2506.2005
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