Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

X inactivation involves the stable silencing of one of the two X chromosomes in XX female mammals. Initiation of this process occurs during early development and involves Xist (X-inactive-specific transcript) RNA coating and the recruitment of Polycomb repressive complex (PRC) 2 and PRC1 proteins. T...

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Bibliografiske detaljer
Main Authors: Hernández-Muñoz, Inmaculada, Lund, Anders H., van der Stoop, Petra, Boutsma, Erwin, Muijrers, Inhua, Verhoeven, Els, Nusinow, Dmitri A., Panning, Barbara, Marahrens, York, van Lohuizen, Maarten
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140410/
https://ncbi.nlm.nih.gov/pubmed/15897469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408918102
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