Strict Control of Human Immunodeficiency Virus Type 1 Replication by a Genetic Switch: Tet for Tat

Live-attenuated human immunodeficiency virus type 1 (HIV-1) variants have shown great promise as AIDS vaccines, but continued replication can lead to the selection of faster-replicating variants that are pathogenic. We therefore designed HIV-1 genomes that replicate exclusively upon addition of the...

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Bibliographic Details
Main Authors: Verhoef, Koen, Marzio, Giuseppe, Hillen, Wolfgang, Bujard, Hermann, Berkhout, Ben
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113994/
https://ncbi.nlm.nih.gov/pubmed/11134311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.2.979-987.2001
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