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Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes

Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K (phosphoinositide 3-kinase)-dependent...

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Bibliografiske detaljer
Main Authors: Hers, Ingeborg, Tavaré, Jeremy M.
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1138980/
https://ncbi.nlm.nih.gov/pubmed/15713122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041531
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