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Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K (phosphoinositide 3-kinase)-dependent...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Portland Press Ltd.
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1138980/ https://ncbi.nlm.nih.gov/pubmed/15713122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041531 |
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