Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.

Signalling by the insulin receptor substrate (IRS) proteins is critically dependent on the tyrosine phosphorylation of specific binding sites that recruit Src homology 2 (SH2)-domain-containing proteins, such as the p85 subunit of phosphoinositide 3-kinase (PI 3-kinase), the tyrosine phosphatase SHP...

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Bibliographische Detailangaben
Hauptverfasser: Hers, Ingeborg, Bell, Christopher J, Poole, Alastair W, Jiang, Donyang, Denton, Richard M, Schaefer, Erik, Tavaré, Jeremy M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223033/
https://ncbi.nlm.nih.gov/pubmed/12220227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020903
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