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Release of replication termination controls mitochondrial DNA copy number after depletion with 2′,3′-dideoxycytidine

Although cellular mitochondrial DNA (mtDNA) copy number varies widely among cell lines and tissues, little is known about the mechanism of mtDNA copy number control. Most nascent replication strands from the leading, heavy-strand origin (O(H)) are prematurely terminated, defining the 3′ boundary of...

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Autors principals: Brown, Timothy A., Clayton, David A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC113833/
https://ncbi.nlm.nih.gov/pubmed/11972339
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