Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.

A factor VIII variant has been characterized in which the heavy chain is directly fused to the light chain. Des-(741-1668)-factor VIII lacks the processing site at Arg1648, as Arg740 of the heavy chain is fused to Ser1669 of the light chain. The sequence of the fusion site is similar to that of othe...

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Detalhes bibliográficos
Main Authors: Donath, M J, de Laaf, R T, Biessels, P T, Lenting, P J, van de Loo, J W, van Mourik, J A, Voorberg, J, Mertens, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136225/
https://ncbi.nlm.nih.gov/pubmed/7492334
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