Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.

A factor VIII variant has been characterized in which the heavy chain is directly fused to the light chain. Des-(741-1668)-factor VIII lacks the processing site at Arg1648, as Arg740 of the heavy chain is fused to Ser1669 of the light chain. The sequence of the fusion site is similar to that of othe...

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Dettagli Bibliografici
Autori principali: Donath, M J, de Laaf, R T, Biessels, P T, Lenting, P J, van de Loo, J W, van Mourik, J A, Voorberg, J, Mertens, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136225/
https://ncbi.nlm.nih.gov/pubmed/7492334
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