Breakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates.

With peptide analogues of their natural substrates (the glycopeptide units of nascent peptidoglycan), the DD-peptidases exhibit a strict preference for D-Ala-D-Xaa C-termini. Gly is tolerated as the C-terminal residue, but with a significantly decreased activity. These enzymes were also known to hyd...

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Bibliografiske detaljer
Main Authors: Damblon, C, Zhao, G H, Jamin, M, Ledent, P, Dubus, A, Vanhove, M, Raquet, X, Christiaens, L, Frère, J M
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1135750/
https://ncbi.nlm.nih.gov/pubmed/7626006
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