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The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27(Kip1) are functional homologues with a structurally conserved inhibitory domain
In Saccharomyces cerevisiae, Sic1, an inhibitor of Cdk (cyclin-dependent kinase), blocks the activity of S-Cdk1 (Cdk1/Clb5,6) kinase that is required for DNA replication. Deletion of Sic1 causes premature DNA replication from fewer origins, extension of the S phase and inefficient separation of sist...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Portland Press Ltd.
2005
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134993/ https://ncbi.nlm.nih.gov/pubmed/15649124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041299 |
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