The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27(Kip1) are functional homologues with a structurally conserved inhibitory domain

In Saccharomyces cerevisiae, Sic1, an inhibitor of Cdk (cyclin-dependent kinase), blocks the activity of S-Cdk1 (Cdk1/Clb5,6) kinase that is required for DNA replication. Deletion of Sic1 causes premature DNA replication from fewer origins, extension of the S phase and inefficient separation of sist...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Barberis, Matteo, De Gioia, Luca, Ruzzene, Maria, Sarno, Stefania, Coccetti, Paola, Fantucci, Piercarlo, Vanoni, Marco, Alberghina, Lilia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Portland Press Ltd. 2005
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134993/
https://ncbi.nlm.nih.gov/pubmed/15649124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041299
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla