The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27(Kip1) are functional homologues with a structurally conserved inhibitory domain

In Saccharomyces cerevisiae, Sic1, an inhibitor of Cdk (cyclin-dependent kinase), blocks the activity of S-Cdk1 (Cdk1/Clb5,6) kinase that is required for DNA replication. Deletion of Sic1 causes premature DNA replication from fewer origins, extension of the S phase and inefficient separation of sist...

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Detaylı Bibliyografya
Asıl Yazarlar: Barberis, Matteo, De Gioia, Luca, Ruzzene, Maria, Sarno, Stefania, Coccetti, Paola, Fantucci, Piercarlo, Vanoni, Marco, Alberghina, Lilia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Portland Press Ltd. 2005
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134993/
https://ncbi.nlm.nih.gov/pubmed/15649124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041299
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