Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms

The effect of liver growth stimulation [using the rodent PXR (pregnane X receptor) activator PCN (pregnenolone-16α-carbonitrile)] in rats chronically treated with carbon tetrachloride to cause repeated hepatocyte necrosis and liver fibrogenesis was examined. PCN did not inhibit the hepatotoxicity of...

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Main Authors: Marek, Carylyn J., Tucker, Steven J., Konstantinou, Dimitrios K., Elrick, Lucy J., Haefner, Dee, Sigalas, Charalambos, Murray, Graeme I., Goodwin, Bryan, Wright, Matthew C.
格式: Artigo
語言:Inglês
出版: Portland Press Ltd. 2005
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134989/
https://ncbi.nlm.nih.gov/pubmed/15595924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041598
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