NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-β (transforming growth factor-β) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-β type I receptor

Inhibitory Smad, Smad7, is a potent inhibitor of TGF-β (transforming growth factor-β) superfamily signalling. By binding to activated type I receptors, it prevents the activation of R-Smads (receptor-regulated Smads). To identify new components of the Smad pathway, we performed yeast two-hybrid scre...

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Hlavní autoři: Kuratomi, Go, Komuro, Akiyoshi, Goto, Kouichiro, Shinozaki, Masahiko, Miyazawa, Keiji, Miyazono, Kohei, Imamura, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2005
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134864/
https://ncbi.nlm.nih.gov/pubmed/15496141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040738
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