Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2)

The human BCRP (breast cancer resistance protein, also known as ABCG2) is an ABC (ATP-binding cassette) transporter that extrudes various anticancer drugs from cells, causing multidrug resistance. To study the molecular determinants of drug specificity of BCRP in more detail, we have expressed wild-...

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Bibliographic Details
Main Authors: Janvilisri, Tavan, Shahi, Sanjay, Venter, Henrietta, Balakrishnan, Lekshmy, van Veen, Hendrik W.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134712/
https://ncbi.nlm.nih.gov/pubmed/15362954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040791
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