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Comparative analysis of topoisomerase IB inhibition and DNA intercalation by flavonoids and similar compounds: structural determinates of activity

Flavonoids and other polyphenolic compounds have been shown to inhibit human topoisomerase IB (topo I) through both inhibition of relaxation activity and through stabilization of the cleavable complex (poisoning). Some flavonoids have also been shown to intercalate DNA, and an association of topoiso...

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Hlavní autoři: Webb, Michael R., Ebeler, Susan E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134138/
https://ncbi.nlm.nih.gov/pubmed/15312049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040474
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