Guanidinium chloride denaturation of the dimeric Bacillus licheniformis BlaI repressor highlights an independent domain unfolding pathway

The Bacillus licheniformis 749/I BlaI repressor is a prokaryotic regulator that, in the absence of a β-lactam antibiotic, prevents the transcription of the blaP gene, which encodes the BlaP β-lactamase. The BlaI repressor is composed of two structural domains. The 82-residue NTD (N-terminal domain)...

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Detalhes bibliográficos
Main Authors: Vreuls, Christelle, Filée, Patrice, Van Melckebeke, Hélène, Aerts, Tony, De Deyn, Peter, Llabrès, Gabriel, Matagne, André, Simorre, Jean-Pierre, Frère, Jean-Marie, Joris, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2004
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134101/
https://ncbi.nlm.nih.gov/pubmed/15285720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040658
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