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Activation of PPARγ is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro

During liver fibrogenesis, quiescent HSC (hepatic stellate cells) become active, a transformation that is associated with enhanced cell proliferation and overproduction of ECM (extracellular matrix). Inhibition of cell proliferation and induction of apoptosis are potential strategies to block the ac...

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Autori principali: Zheng, Shizhong, Chen, Anping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134098/
https://ncbi.nlm.nih.gov/pubmed/15320868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040928
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